GFI1-Dependent Repression of <i>SGPP1</i> Increases Multiple Myeloma Cell Survival

GFI1-Dependent Repression of <i>SGPP1</i> Increases Multiple Myeloma Cell Survival

Multiple myeloma (MM) remains incurable for most patients due to the emergence of drug resistant clones. Here we report a p53-independent mechanism responsible for Growth Factor Independence-1 (GFI1) support of MM cell survival by its modulation of sphingolipid metabolism to increase the sphingosine...

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Bibliographic Details
Main Authors: Daniela N. Petrusca, Patrick L. Mulcrone, David A. Macar, Ryan T. Bishop, Evgeny Berdyshev, Attaya Suvannasankha, Judith L. Anderson, Quanhong Sun, Philip E. Auron, Deborah L. Galson, G. David Roodman
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
GFI1
multiple myeloma
SGPP1
S1P
c-Myc
PP2A
Online Access:https://www.mdpi.com/2072-6694/14/3/772

Internet

https://www.mdpi.com/2072-6694/14/3/772

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