Abnormal adipogenic signaling in the bone marrow mesenchymal stem cells contributes to supportive microenvironment for leukemia development

Abnormal adipogenic signaling in the bone marrow mesenchymal stem cells contributes to supportive microenvironment for leukemia development

Abstract Background Acute myeloid leukemia (AML) is an aggressive hematological malignancy, associated with unfavorable patient outcome, primarily due to disease relapse. Mesenchymal stem cells (MSCs) residing in the bone marrow (BM) niche are the source of mesenchyma-derived subpopulations, includi...

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Bibliographic Details
Main Authors: Rawan Sabbah, Sahar Saadi, Tal Shahar-Gabay, Shiran Gerassy, Shlomit Yehudai-Resheff, Tsila Zuckerman
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Cell Communication and Signaling
Subjects:
Mesenchymal stem cells
Bone marrow niche
Acute myeloid leukemia
Adipocytes
Osteocytes
Online Access:https://doi.org/10.1186/s12964-023-01231-z

Internet

https://doi.org/10.1186/s12964-023-01231-z

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