Structure Based Affinity Maturation and Characterizing of SARS-CoV Antibody CR3022 against SARS-CoV-2 by Computational and Experimental Approaches

The COVID-19 epidemic is raging around the world. Neutralizing antibodies are powerful tools for the prevention and treatment of SARS-CoV-2 infection. Antibody CR3022, a SARS-CoV neutralizing antibody, was found to cross-react with SARS-CoV-2, but its affinity was lower than that of its binding with...

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Bibliographic Details
Main Authors: Wei Yu, Nan Zhong, Xin Li, Jiayi Ren, Yueming Wang, Chengming Li, Gui Yao, Rui Zhu, Xiaoli Wang, Zhenxing Jia, Changwen Wu, Rongfeng Chen, Weihong Zheng, Huaxin Liao, Xiaomin Wu, Xiaohui Yuan
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/14/2/186