27-Hydroxycholesterol impairs learning and memory ability via decreasing brain glucose uptake mediated by the gut microbiota

27-Hydroxycholesterol impairs learning and memory ability via decreasing brain glucose uptake mediated by the gut microbiota

Brain glucose hypometabolism is a significant manifestation of Alzheimer’s disease (AD). 27-hydroxycholesterol (27-OHC) and the gut microbiota have been recognized as factors possibly influencing the pathogenesis of AD. This study aimed to investigate the link between 27-OHC, the gut microbiota, and...

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Bibliographic Details
Main Authors: Ling Hao, Lijing Wang, Mengwei Ju, Wenjing Feng, Zhiting Guo, Xuejing Sun, Rong Xiao
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
27-Hydroxycholesterol
Brain glucose uptake
Gut microbiota
Learning and memory ability
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223014476

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http://www.sciencedirect.com/science/article/pii/S0753332223014476

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