Double systemic cytokine release syndrome following sequential infusion of anti-CD22 and anti-CD19 chimeric antigen receptor T cells after autologous hematopoietic stem cell transplantation for a central diffuse large B-cell lymphoma patient: A case report and literature review

Double systemic cytokine release syndrome following sequential infusion of anti-CD22 and anti-CD19 chimeric antigen receptor T cells after autologous hematopoietic stem cell transplantation for a central diffuse large B-cell lymphoma patient: A case report and literature review

BackgroundChimeric Antigen Receptor T cell(CAR T-cell) therapy has been a great success in relapsed/refractory acute B lymphoblastic leukemia and B-cell lymphoma. At the same time, there are also related adverse reactions, especially cytokine release syndrome(CRS) and immune effector cell associated...

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Bibliographic Details
Main Authors: Jing Zheng, Yao Xiao, Xue Q. Wu, Qiong Z. Xiao, Chun Feng, Kai B. Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor T cell
cytokine release syndrome
central diffuse large B-cell lymphoma
immunotherapy
adverse reactions
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1098815/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1098815/full

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