Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production

Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production

Abstract Benzylisoquinoline alkaloids (BIAs) are a type of secondary metabolite with clinical application value. (S)-stylopine is a special BIA which contains methylenedioxy bridge structures. CYP719As could catalyze the methylenedioxy bridge-formation on the A or D rings of protoberberine alkaloids...

Full description

Bibliographic Details
Main Authors: Xiuyu Liu, Xiang Jiao, Yatian Cheng, Ying Ma, Junling Bu, Baolong Jin, Qishuang Li, Zhimin Hu, Jinfu Tang, Changjiangsheng Lai, Jian Wang, Guanghong Cui, Yun Chen, Juan Guo, Luqi Huang
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Microbial Cell Factories
Subjects:
CyCYP719As
Benzylisoquinoline alkaloids (BIAs)
Corydalis yanhusuo
Methylenedioxy bridge-formation
Regiospecificity
Synthetic biology
Online Access:https://doi.org/10.1186/s12934-023-02024-2

Internet

https://doi.org/10.1186/s12934-023-02024-2

Similar Items