Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production

Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production

Abstract Benzylisoquinoline alkaloids (BIAs) are a type of secondary metabolite with clinical application value. (S)-stylopine is a special BIA which contains methylenedioxy bridge structures. CYP719As could catalyze the methylenedioxy bridge-formation on the A or D rings of protoberberine alkaloids...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Xiuyu Liu, Xiang Jiao, Yatian Cheng, Ying Ma, Junling Bu, Baolong Jin, Qishuang Li, Zhimin Hu, Jinfu Tang, Changjiangsheng Lai, Jian Wang, Guanghong Cui, Yun Chen, Juan Guo, Luqi Huang
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: BMC 2023-02-01
Cyfres:Microbial Cell Factories
Pynciau:
CyCYP719As
Benzylisoquinoline alkaloids (BIAs)
Corydalis yanhusuo
Methylenedioxy bridge-formation
Regiospecificity
Synthetic biology
Mynediad Ar-lein:https://doi.org/10.1186/s12934-023-02024-2

Rhyngrwyd

https://doi.org/10.1186/s12934-023-02024-2

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