Structure-function analysis of CYP719As involved in methylenedioxy bridge-formation in the biosynthesis of benzylisoquinoline alkaloids and its de novo production
Abstract Benzylisoquinoline alkaloids (BIAs) are a type of secondary metabolite with clinical application value. (S)-stylopine is a special BIA which contains methylenedioxy bridge structures. CYP719As could catalyze the methylenedioxy bridge-formation on the A or D rings of protoberberine alkaloids...
Main Authors: | Xiuyu Liu, Xiang Jiao, Yatian Cheng, Ying Ma, Junling Bu, Baolong Jin, Qishuang Li, Zhimin Hu, Jinfu Tang, Changjiangsheng Lai, Jian Wang, Guanghong Cui, Yun Chen, Juan Guo, Luqi Huang |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-02-01
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Series: | Microbial Cell Factories |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12934-023-02024-2 |
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