Enhancement of radiation therapy by indoleamine 2,3 dioxygenase 1 inhibition through multimodal mechanisms

Enhancement of radiation therapy by indoleamine 2,3 dioxygenase 1 inhibition through multimodal mechanisms

Abstract Background Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that converts tryptophan to kynurenine. IDO1 expression is found not only in tumor cells but also in immune cells and is associated with tumor proliferation and immune responses. IDO1 inhibitors and radiation may cooperatively sup...

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Bibliographic Details
Main Authors: Hiroaki Nozawa, Tetsuro Taira, Hirofumi Sonoda, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Yuzo Nagai, Shinya Abe, Soichiro Ishihara
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Cancer
Subjects:
Indoleamine 2,3 dioxygenase 1
Colorectal cancer
Radiation therapy
Wnt/β-catenin pathway
Online Access:https://doi.org/10.1186/s12885-023-10539-5

Internet

https://doi.org/10.1186/s12885-023-10539-5

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