Exogenous proline enhances susceptibility of NSCLC to cisplatin via metabolic reprogramming and PLK1-mediated cell cycle arrest

Exogenous proline enhances susceptibility of NSCLC to cisplatin via metabolic reprogramming and PLK1-mediated cell cycle arrest

The occurrence of cisplatin resistance is still the main factor limiting the therapeutic effect of non-small cell lung cancer (NSCLC). It is urgent to elucidate the resistance mechanism and develop novel treatment strategies. Targeted metabolomics was first performed to detect amino acids’ content i...

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Bibliographic Details
Main Authors: Bingjie Han, Yuanyuan Sun, Xiaofen Zhang, Ping Yue, Meiling Tian, Dan Yan, Fanxiang Yin, Bo Qin, Yi Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
cisplatin resistance
metabolic reprogramming
NSCLC
proline
plk1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.942261/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.942261/full

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