Mapping the APP/Presenilin (PS) Binding Domains: The Hydrophilic N-Terminus of PS2 Is Sufficient for Interaction with APP and Can Displace APP/PS1 Interaction

Mapping the APP/Presenilin (PS) Binding Domains: The Hydrophilic N-Terminus of PS2 Is Sufficient for Interaction with APP and Can Displace APP/PS1 Interaction

Mutations in presenilin 1 and presenilin 2 (PS1 and PS2, respectively) genes cause the large majority of familial forms of early-onset Alzheimer's disease. The physical interaction between presenilins and APP has been recently described using coimmunoprecipitation. With a similar technique, we...

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Bibliographic Details
Main Authors: Laurent Pradier, Nathalie Carpentier, Laurence Delalonde, Nicole Clavel, Marie-Dominique Bock, Luc Buée, Luc Mercken, Bruno Tocqué, Christian Czech
Format: Article
Language:English
Published: Elsevier 1999-02-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996198902121

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http://www.sciencedirect.com/science/article/pii/S0969996198902121

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