Subdiaphragmatic Vagotomy With Pyloroplasty Ameliorates the Obesity Caused by Genetic Deletion of the Melanocortin 4 Receptor in the Mouse

Subdiaphragmatic Vagotomy With Pyloroplasty Ameliorates the Obesity Caused by Genetic Deletion of the Melanocortin 4 Receptor in the Mouse

Background/Objectives: We tested the hypothesis that abolishing vagal nerve activity will reverse the obesity phenotype of melanocortin 4 receptor knockout mice (Mc4r−/−).Subjects/Methods: In two separate studies, we examined the efficacy of bilateral subdiaphragmatic vagotomy (SDV) with pyloroplast...

Full description

Bibliographic Details
Main Authors: Ghazaul Dezfuli, Richard A. Gillis, Jaclyn E. Tatge, Kimbell R. Duncan, Kenneth L. Dretchen, Patrick G. Jackson, Joseph G. Verbalis, Niaz Sahibzada
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Neuroscience
Subjects:
vagotomy
weight loss
surgery
melanocortin
food intake
body weight
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00104/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00104/full

Similar Items