Generalized Modules for Membrane Antigens as Carrier for Polysaccharides: Impact of Sugar Length, Density, and Attachment Site on the Immune Response Elicited in Animal Models

Generalized Modules for Membrane Antigens as Carrier for Polysaccharides: Impact of Sugar Length, Density, and Attachment Site on the Immune Response Elicited in Animal Models

Nanoparticle systems are being explored for the display of carbohydrate antigens, characterized by multimeric presentation of glycan epitopes and special chemico-physical properties of nano-sized particles. Among them, outer membrane vesicles (OMVs) are receiving great attention, combining antigen p...

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Bibliographic Details
Main Authors: Francesca Micoli, Renzo Alfini, Roberta Di Benedetto, Francesca Necchi, Fabiola Schiavo, Francesca Mancini, Martina Carducci, Davide Oldrini, Olimpia Pitirollo, Gianmarco Gasperini, Cristiana Balocchi, Nicoletta Bechi, Brunella Brunelli, Diego Piccioli, Roberto Adamo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
glycoconjugate
GMMA
carrier protein
polysaccharide
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.719315/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.719315/full

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