HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status

HLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status

Abstract Background Haplotypes defined by amino acids at HLA-DRB1 positions 11, 71 and 74 associated with susceptibility to rheumatoid arthritis (RA) are associated with radiological outcome, anti-TNF response and all cause-mortality in RA. RA is associated with cardiovascular (CV) morbidity and mor...

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Bibliographic Details
Main Authors: Seema Sharma, Darren Plant, John Bowes, Alex Macgregor, Suzanne Verstappen, Anne Barton, Sebastien Viatte
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Arthritis Research & Therapy
Subjects:
Cardiovascular mortality
Genetic biomarkers
HLA-DRB1
Rheumatoid arthritis
Anti-citrullinated protein antibodies
Online Access:https://doi.org/10.1186/s13075-022-02775-0

Internet

https://doi.org/10.1186/s13075-022-02775-0

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