Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3β Signaling

Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3β Signaling

Copper (Cu) is essential for multiple biochemical processes, and copper sulphate (CuSO<sub>4</sub>) is a pesticide used for repelling pests. Accidental or intentional intoxication can induce multiorgan toxicity and could be fatal. Curcumin (CUR) is a potent antioxidant, but its poor syst...

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Bibliographic Details
Main Authors: Wedad S. Sarawi, Ahlam M. Alhusaini, Laila M. Fadda, Hatun A. Alomar, Awatif B. Albaker, Amjad S. Aljrboa, Areej M. Alotaibi, Iman H. Hasan, Ayman M. Mahmoud
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
curcumin
GSK-3β
inflammation
DNA damage
oxidative stress
Online Access:https://www.mdpi.com/1420-3049/26/18/5591

Internet

https://www.mdpi.com/1420-3049/26/18/5591

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