Therapies beyond Physiological Barriers and Drug Resistance: A Pilot Study and Review of the Literature Investigating If Intrathecal Trastuzumab and New Treatment Options Can Improve Oncologic Outcomes in Leptomeningeal Metastases from HER2-Positive Breast Cancer

Therapies beyond Physiological Barriers and Drug Resistance: A Pilot Study and Review of the Literature Investigating If Intrathecal Trastuzumab and New Treatment Options Can Improve Oncologic Outcomes in Leptomeningeal Metastases from HER2-Positive Breast Cancer

Leptomeningeal metastases (LM) are a rare but rapidly fatal complication defined by the spread of tumor cells within the leptomeninges and the subarachnoid space, found in approximately 10% of patients with HER2-positive breast cancers. This pilot study evaluated the efficacy of local treatment with...

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Bibliographic Details
Main Authors: Oana Gabriela Trifănescu, Dan Mitrea, Laurenția Nicoleta Galeș, Ana Ciornei, Mihai-Andrei Păun, Ioana Butnariu, Raluca Alexandra Trifănescu, Natalia Motaș, Radu Valeriu Toma, Liviu Bîlteanu, Mirela Gherghe, Rodica Maricela Anghel
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cancers
Subjects:
intrathecal treatment
leptomeningeal metastasis
breast cancer
intrathecal trastuzumab
Online Access:https://www.mdpi.com/2072-6694/15/9/2508

Internet

https://www.mdpi.com/2072-6694/15/9/2508

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