Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia

Abstract Introduction Synaptic membrane formation depends on nutrients that fuel metabolic pathways for the synthesis of constituent phospholipids. Consequently, insufficient availability of such nutrients may restrict membrane formation and contribute to synaptic dysfunction in Alzheimer's dis...

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Bibliographic Details
Main Authors: Nick vanWijk, Rosalinde E.R. Slot, Flora H. Duits, Marieke Strik, Egbert Biesheuvel, John W.C. Sijben, Marinus A. Blankenstein, Jörgen Bierau, Wiesje M. van derFlier, Philip Scheltens, Charlotte E. Teunissen
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Online Access:https://doi.org/10.1016/j.dadm.2017.04.005