Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia
Abstract Introduction Synaptic membrane formation depends on nutrients that fuel metabolic pathways for the synthesis of constituent phospholipids. Consequently, insufficient availability of such nutrients may restrict membrane formation and contribute to synaptic dysfunction in Alzheimer's dis...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2017.04.005 |
| _version_ | 1818923108392763392 |
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| author | Nick vanWijk Rosalinde E.R. Slot Flora H. Duits Marieke Strik Egbert Biesheuvel John W.C. Sijben Marinus A. Blankenstein Jörgen Bierau Wiesje M. van derFlier Philip Scheltens Charlotte E. Teunissen |
| author_facet | Nick vanWijk Rosalinde E.R. Slot Flora H. Duits Marieke Strik Egbert Biesheuvel John W.C. Sijben Marinus A. Blankenstein Jörgen Bierau Wiesje M. van derFlier Philip Scheltens Charlotte E. Teunissen |
| author_sort | Nick vanWijk |
| collection | DOAJ |
| description | Abstract Introduction Synaptic membrane formation depends on nutrients that fuel metabolic pathways for the synthesis of constituent phospholipids. Consequently, insufficient availability of such nutrients may restrict membrane formation and contribute to synaptic dysfunction in Alzheimer's disease (AD). We assessed whether blood and cerebrospinal fluid (CSF) concentrations of nutrients related to phospholipid synthesis differ among patients with AD, mild cognitive impairment (MCI), and control subjects. Methods Concentrations of uridine, choline, folate, homocysteine, and other related metabolites were analyzed in paired blood and CSF samples from subjects selected from the Amsterdam Dementia Cohort with AD (n = 150; age, 66 ± 7 years; 37% female), MCI (n = 148; age, 66 ± 8 years; 37% female), and control subjects (n = 148; age, 59 ± 8 years; 38% female). Results Age‐ and gender‐adjusted analysis of variance revealed different concentrations of circulating uridine, choline, and folate and CSF uridine, folate, and homocysteine (all P < .05) among the three diagnostic groups. Post hoc pairwise comparison showed that subjects with AD had lower CSF uridine, plasma choline and higher CSF homocysteine concentrations, whereas subjects with MCI had lower plasma and CSF uridine, serum and CSF folate, and higher CSF homocysteine concentrations compared with control subjects (all P < .05), with differences ranging from −11 to +22%. Discussion AD and MCI patients have lower levels of nutrients involved in phospholipid synthesis. The current observations warrant exploration of the application of nutritional strategies in the early stages of AD. |
| first_indexed | 2024-12-20T02:04:11Z |
| format | Article |
| id | doaj.art-e756096f97ea446e88e81b4531593a4c |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-12-20T02:04:11Z |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-e756096f97ea446e88e81b4531593a4c2022-12-21T19:57:15ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292017-01-018113914610.1016/j.dadm.2017.04.005Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementiaNick vanWijk0Rosalinde E.R. Slot1Flora H. Duits2Marieke Strik3Egbert Biesheuvel4John W.C. Sijben5Marinus A. Blankenstein6Jörgen Bierau7Wiesje M. van derFlier8Philip Scheltens9Charlotte E. Teunissen10Nutricia Advanced Medical Nutrition, Nutricia ResearchUtrechtThe NetherlandsAlzheimer Center and Department of NeurologyVU University Medical CenterAmsterdamThe NetherlandsAlzheimer Center and Department of NeurologyVU University Medical CenterAmsterdamThe NetherlandsDepartment of Clinical ChemistryVU University Medical CenterAmsterdamThe NetherlandsNutricia Advanced Medical Nutrition, Nutricia ResearchUtrechtThe NetherlandsNutricia Advanced Medical Nutrition, Nutricia ResearchUtrechtThe NetherlandsDepartment of Clinical ChemistryVU University Medical CenterAmsterdamThe NetherlandsDepartment of Clinical GeneticsMaastricht UMC+MaastrichtThe NetherlandsAlzheimer Center and Department of NeurologyVU University Medical CenterAmsterdamThe NetherlandsAlzheimer Center and Department of NeurologyVU University Medical CenterAmsterdamThe NetherlandsDepartment of Clinical ChemistryVU University Medical CenterAmsterdamThe NetherlandsAbstract Introduction Synaptic membrane formation depends on nutrients that fuel metabolic pathways for the synthesis of constituent phospholipids. Consequently, insufficient availability of such nutrients may restrict membrane formation and contribute to synaptic dysfunction in Alzheimer's disease (AD). We assessed whether blood and cerebrospinal fluid (CSF) concentrations of nutrients related to phospholipid synthesis differ among patients with AD, mild cognitive impairment (MCI), and control subjects. Methods Concentrations of uridine, choline, folate, homocysteine, and other related metabolites were analyzed in paired blood and CSF samples from subjects selected from the Amsterdam Dementia Cohort with AD (n = 150; age, 66 ± 7 years; 37% female), MCI (n = 148; age, 66 ± 8 years; 37% female), and control subjects (n = 148; age, 59 ± 8 years; 38% female). Results Age‐ and gender‐adjusted analysis of variance revealed different concentrations of circulating uridine, choline, and folate and CSF uridine, folate, and homocysteine (all P < .05) among the three diagnostic groups. Post hoc pairwise comparison showed that subjects with AD had lower CSF uridine, plasma choline and higher CSF homocysteine concentrations, whereas subjects with MCI had lower plasma and CSF uridine, serum and CSF folate, and higher CSF homocysteine concentrations compared with control subjects (all P < .05), with differences ranging from −11 to +22%. Discussion AD and MCI patients have lower levels of nutrients involved in phospholipid synthesis. The current observations warrant exploration of the application of nutritional strategies in the early stages of AD.https://doi.org/10.1016/j.dadm.2017.04.005Nutritional statusUridineCholineFolateHomocysteineBlood |
| spellingShingle | Nick vanWijk Rosalinde E.R. Slot Flora H. Duits Marieke Strik Egbert Biesheuvel John W.C. Sijben Marinus A. Blankenstein Jörgen Bierau Wiesje M. van derFlier Philip Scheltens Charlotte E. Teunissen Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Nutritional status Uridine Choline Folate Homocysteine Blood |
| title | Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia |
| title_full | Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia |
| title_fullStr | Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia |
| title_full_unstemmed | Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia |
| title_short | Nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and Alzheimer's disease dementia |
| title_sort | nutrients required for phospholipid synthesis are lower in blood and cerebrospinal fluid in mild cognitive impairment and alzheimer s disease dementia |
| topic | Nutritional status Uridine Choline Folate Homocysteine Blood |
| url | https://doi.org/10.1016/j.dadm.2017.04.005 |
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