Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions

Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions

Amorphous solid dispersion (ASD) is one of the most promising formulation technologies for improving the oral absorption of poorly soluble drugs, where the maintenance of supersaturation plays a key role in enhancing the absorption process. However, quantitative prediction of oral absorption from AS...

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Bibliographic Details
Main Authors: Kyosuke Suzuki, Kohsaku Kawakami, Masafumi Fukiage, Michinori Oikawa, Yohei Nishida, Maki Matsuda, Takuya Fujita
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
amorphous solid dispersions
albendazole
oral absorption
liquid-liquid phase separation
dissolution study
supersaturation
Online Access:https://www.mdpi.com/1999-4923/13/2/220

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https://www.mdpi.com/1999-4923/13/2/220

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