A high-resolution route map reveals distinct stages of chondrocyte dedifferentiation for cartilage regeneration

Abstract Articular cartilage damage is a universal health problem. Despite recent progress, chondrocyte dedifferentiation has severely compromised the clinical outcomes of cell-based cartilage regeneration. Loss-of-function changes are frequently observed in chondrocyte expansion and other pathologi...

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Bibliographic Details
Main Authors: Yishan Chen, Yeke Yu, Ya Wen, Juan Chen, Junxin Lin, Zixuan Sheng, Wenyan Zhou, Heng Sun, Chengrui An, Jiansong Chen, Weiliang Wu, Chong Teng, Wei Wei, Hongwei Ouyang
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-022-00209-w