Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs

Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs

The formation of small Aβ42 oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk factor, phosphatidylinositol binding clathrin assembly protein (PICALM), reduc...

Full description

Bibliographic Details
Main Authors: Sei-Kyoung Park, Kiira Ratia, Mariam Ba, Maria Valencik, Susan W. Liebman
Format: Article
Language:English
Published: Shared Science Publishers OG 2016-01-01
Series:Microbial Cell
Subjects:
Aβ42 oligomerization
yeast
HTS
PICALM
Alzheimer
Online Access:http://microbialcell.com/researcharticles/inhibition-of-a%CE%B242-oligomerization-in-yeast-by-a-picalm-ortholog-and-certain-fda-approved-drugs/

Internet

http://microbialcell.com/researcharticles/inhibition-of-a%CE%B242-oligomerization-in-yeast-by-a-picalm-ortholog-and-certain-fda-approved-drugs/

Similar Items