Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs

Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs

The formation of small Aβ42 oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk factor, phosphatidylinositol binding clathrin assembly protein (PICALM), reduc...

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Chi tiết về thư mục
Những tác giả chính: Sei-Kyoung Park, Kiira Ratia, Mariam Ba, Maria Valencik, Susan W. Liebman
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Shared Science Publishers OG 2016-01-01
Loạt:Microbial Cell
Những chủ đề:
Aβ42 oligomerization
yeast
HTS
PICALM
Alzheimer
Truy cập trực tuyến:http://microbialcell.com/researcharticles/inhibition-of-a%CE%B242-oligomerization-in-yeast-by-a-picalm-ortholog-and-certain-fda-approved-drugs/

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http://microbialcell.com/researcharticles/inhibition-of-a%CE%B242-oligomerization-in-yeast-by-a-picalm-ortholog-and-certain-fda-approved-drugs/

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