Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs
The formation of small Aβ42 oligomers has been implicated as a toxic species in Alzheimer disease (AD). In strong support of this hypothesis we found that overexpression of Yap1802, the yeast ortholog of the human AD risk factor, phosphatidylinositol binding clathrin assembly protein (PICALM), reduc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shared Science Publishers OG
2016-01-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/inhibition-of-a%CE%B242-oligomerization-in-yeast-by-a-picalm-ortholog-and-certain-fda-approved-drugs/ |