Oridonin induces Mdm2‐p60 to promote p53‐mediated apoptosis and cell cycle arrest in neuroblastoma

Oridonin induces Mdm2‐p60 to promote p53‐mediated apoptosis and cell cycle arrest in neuroblastoma

Abstract Oridonin could induce NB (neuroblastoma) cells growth inhibition by inducing apoptosis and cell cycle arrest, and the molecular mechanisms behind the effects deserve to be further explored. Here, oridonin was confirmed to cause the reactivation of p53 (cellular tumor antigen p53) to promote...

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Bibliographic Details
Main Authors: Han‐Qing Zhu, Chao Zhang, Zhu‐Ying Guo, Jun‐Mei Yang, Jia‐Hui Guo, Chen Chen, Qiang‐Hua Yao, Feng Liu, Quan‐Wu Zhang, Feng‐Hou Gao
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Cancer Medicine
Subjects:
apoptosis
cell cycle arrest
Mdm2‐p60
Oridonin
p53
ROS
Online Access:https://doi.org/10.1002/cam4.2393

Internet

https://doi.org/10.1002/cam4.2393

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