Single Cell Transcriptome and Surface Epitope Analysis of Ankylosing Spondylitis Facilitates Disease Classification by Machine Learning

Single Cell Transcriptome and Surface Epitope Analysis of Ankylosing Spondylitis Facilitates Disease Classification by Machine Learning

Ankylosing spondylitis (AS) is an immune-mediated inflammatory disorder that primarily affects the axial skeleton, especially the sacroiliac joints and spine. This results in chronic back pain and, in extreme cases, ankylosis of the spine. Despite its debilitating effects, the pathogenesis of AS rem...

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Bibliographic Details
Main Authors: Samuel Alber, Sugandh Kumar, Jared Liu, Zhi-Ming Huang, Diana Paez, Julie Hong, Hsin-Wen Chang, Tina Bhutani, Lianne S. Gensler, Wilson Liao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
ankylosing spondylitis
spondyloarthritis
single cell sequencing
CITE-seq
genomics
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.838636/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.838636/full

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