A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens

Objective: Glucose promotes lipid remodelling in pancreatic β-cells, and this is thought to contribute to the regulation of insulin secretion, but the metabolic pathways and potential signalling intermediates have not been fully elaborated. Methods: Using mass spectrometry (MS) we quantified changes...

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Bibliographic Details
Main Authors: Gemma L. Pearson, Natalie Mellett, Kwan Yi Chu, Ebru Boslem, Peter J. Meikle, Trevor J. Biden
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877816300205