Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer

Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer

Histone lysine methyltransferases (HMT) comprise a subclass of epigenetic regulators; dysregulation of these enzymes affects gene expression, which may lead to tumorigenesis. Here, we performed an integrated analysis of 50 HMTs in bladder cancer and found intrinsic links between copy number alterati...

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Bibliographic Details
Main Authors: Beichen Ding, Libin Yan, Yucong Zhang, Zhize Wang, Yangjun Zhang, Ding Xia, Zhangqun Ye, Hua Xu
Format: Article
Language:English
Published: Wiley 2019-04-01
Series:FEBS Open Bio
Subjects:
bladder cancer
copy number
histone lysine methyltransferase
KMT2D
mutations
Online Access:https://doi.org/10.1002/2211-5463.12600

Internet

https://doi.org/10.1002/2211-5463.12600

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