TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway.

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway.

TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3) is a member of the TIM family of proteins that is preferentially expressed on Th1 polarized CD4+ and CD8+ T cells. Recent studies indicate that TIM-3 serves as a negative regulator of T cell function (i.e. T cell dependent immune re...

Descrición completa

Detalles Bibliográficos
Main Authors: Brian Tomkowicz, Eileen Walsh, Adam Cotty, Raluca Verona, Nina Sabins, Fred Kaplan, Sandy Santulli-Marotto, Chen-Ni Chin, Jill Mooney, Russell B Lingham, Michael Naso, Timothy McCabe
Formato: Artigo
Idioma:English
Publicado: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC4619610?pdf=render

Internet

http://europepmc.org/articles/PMC4619610?pdf=render

Títulos similares