Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal.

Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal.

Both the hypothalamus-pituitary-adrenal (HPA) axis and the extrahypothalamic brain stress system are key elements of the neural circuitry that regulates the negative states during abstinence from chronic drug exposure. Orexins have recently been hypothesized to modulate the extended amygdala and to...

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Bibliographic Details
Main Authors: M Luisa Laorden, Szilamér Ferenczi, Bernadett Pintér-Kübler, Laura L González-Martín, M Carmen Lasheras, Krisztina J Kovács, M Victoria Milanés, Cristina Núñez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3348891?pdf=render

Internet

http://europepmc.org/articles/PMC3348891?pdf=render

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