Ablation of Shank3 alleviates cardiac dysfunction in aging mice by promoting CaMKII activation and Parkin-mediated mitophagy

Ablation of Shank3 alleviates cardiac dysfunction in aging mice by promoting CaMKII activation and Parkin-mediated mitophagy

Compromised mitophagy and mitochondrial homeostasis are major contributors for the etiology of cardiac aging, although the precise underlying mechanisms remains elusive. Shank3, a heart-enriched protein, has recently been reported to regulate aging-related neurodegenerative diseases. This study aime...

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Bibliographic Details
Main Authors: Ying Wang, Yuerong Xu, Wangang Guo, Yexian Fang, Lang Hu, Runze Wang, Ran Zhao, Dong Guo, Bingchao Qi, Gaotong Ren, Jun Ren, Yan Li, Mingming Zhang
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Redox Biology
Subjects:
Cardiac aging
Mitophagy
Shank3
CaMKII
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003093

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http://www.sciencedirect.com/science/article/pii/S2213231722003093

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