PEGylation Prolongs the Half-Life of Equine Anti-SARS-CoV-2 Specific F(ab’)<sub>2</sub>

PEGylation Prolongs the Half-Life of Equine Anti-SARS-CoV-2 Specific F(ab’)<sub>2</sub>

Therapeutic antibodies-F(ab’)<sub>2</sub> obtained from hyperimmune equine plasma could treat emerging infectious diseases rapidly because of their high neutralization activity and high output. However, the small-sized F(ab’)<sub>2</sub> is rapidly eliminated by blood circula...

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Bibliographic Details
Main Authors: Mengyuan Xu, Jinhao Bi, Bo Liang, Xinyue Wang, Ruo Mo, Na Feng, Feihu Yan, Tiecheng Wang, Songtao Yang, Yongkun Zhao, Xianzhu Xia
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
SARS-CoV-2
equine polyclonal antibody
specific F(ab’)<sub>2</sub>
PEGylation
pharmacokinetic
Online Access:https://www.mdpi.com/1422-0067/24/4/3387

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https://www.mdpi.com/1422-0067/24/4/3387

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