Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

One of the largest membrane protein families in eukaryotes are G protein-coupled receptors (GPCRs). GPCRs modulate cell physiology by activating diverse intracellular transducers, prominently heterotrimeric G proteins. The recent surge in structural data has expanded our understanding of GPCR-mediat...

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Bibliographic Details
Main Authors: Ching-Ju Tsai, Jacopo Marino, Ricardo Adaixo, Filip Pamula, Jonas Muehle, Shoji Maeda, Tilman Flock, Nicholas MI Taylor, Inayatulla Mohammed, Hugues Matile, Roger JP Dawson, Xavier Deupi, Henning Stahlberg, Gebhard Schertler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
G protein-coupled receptors
G proteins
cryo-EM
Gβ subunit
cellular signaling
Bos taurus
Online Access:https://elifesciences.org/articles/46041

Internet

https://elifesciences.org/articles/46041

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