Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by a Single-Stranded Oligonucleotide

Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by a Single-Stranded Oligonucleotide

Numerous inflammatory skin disorders display a high prevalence of itch. The Mas-related G protein coupled receptor X2 (MRGPRX2) has been shown to modulate itch by inducing non-IgE-mediated mast cell degranulation and the release of endogenous inducers of pruritus. Various substances collectively kno...

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Bibliographic Details
Main Authors: Aleksandra Dondalska, Elin Rönnberg, Haisha Ma, Sandra Axberg Pålsson, Elin Magnusdottir, Tianle Gao, Lucille Adam, Ethan A. Lerner, Gunnar Nilsson, Malin Lagerström, Anna-Lena Spetz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
itch
inflammation
mast cells
rosacea
single-stranded oligonucleotides
compound 48/80
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.559589/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.559589/full

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