High Dose Pharmaceutical Grade Biotin (MD1003) Accelerates Differentiation of Murine and Grafted Human Oligodendrocyte Progenitor Cells In Vivo

High Dose Pharmaceutical Grade Biotin (MD1003) Accelerates Differentiation of Murine and Grafted Human Oligodendrocyte Progenitor Cells In Vivo

Accumulating evidences suggest a strong correlation between metabolic changes and neurodegeneration in CNS demyelinating diseases such as multiple sclerosis (MS). Biotin, an essential cofactor for five carboxylases, is expressed by oligodendrocytes and involved in fatty acid synthesis and energy pro...

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Bibliographic Details
Main Authors: Marion J. F. Levy, Beatriz Garcia-Diaz, Frédéric Sedel, Anne Baron-Van Evercooren, Sabah Mozafari
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
MD1003
murine oligodendrocytes
human oligodendrocytes
humanized animal model
shiverer mice
oligodendrocyte differentiation
Online Access:https://www.mdpi.com/1422-0067/23/24/15733

Internet

https://www.mdpi.com/1422-0067/23/24/15733

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