Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells.

Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells.

The prevailing paradigm of T lymphocyte control of viral replication is that the protective capacity of virus-specific CD8(+) T cells is directly proportional to the number of functions they can perform, with IL-2 production capacity considered critical. Having recently defined rapid perforin upregu...

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Bibliographic Details
Main Authors: George Makedonas, Natalie Hutnick, Danielle Haney, Alexandra C Amick, Jay Gardner, Gabriela Cosma, Adam R Hersperger, Douglas Dolfi, E John Wherry, Guido Ferrari, Michael R Betts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2832688?pdf=render

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http://europepmc.org/articles/PMC2832688?pdf=render

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