Predicting Pharmacokinetic Properties of Potential Anticancer Agents via Their Chromatographic Behavior on Different Reversed Phase Materials

Predicting Pharmacokinetic Properties of Potential Anticancer Agents via Their Chromatographic Behavior on Different Reversed Phase Materials

The Quantitative Structure-Activity Relationship (QSAR) methodology was used to predict biological properties, i.e., the blood–brain distribution (log <i>BB</i>), fraction unbounded in the brain (<i>f</i><sub>u,brain</sub>), water-skin permeation (log <i>K&l...

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Bibliographic Details
Main Authors: Małgorzata Janicka, Anna Mycka, Małgorzata Sztanke, Krzysztof Sztanke
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
micellar chromatography
immobilized artificial membrane chromatography
RP-18e
QSARs
log <i>K</i><sub>p</sub>
log <i>K</i><sub>a,HSA</sub>
Online Access:https://www.mdpi.com/1422-0067/22/8/4257

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https://www.mdpi.com/1422-0067/22/8/4257

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