Critical role for the lung endothelial nonmuscle myosin light‐chain kinase isoform in the severity of inflammatory murine lung injury

Critical role for the lung endothelial nonmuscle myosin light‐chain kinase isoform in the severity of inflammatory murine lung injury

Abstract Global knockout of the nonmuscle isoform of myosin light‐chain kinase (nmMLCK), a primary cellular regulator of cytoskeletal machinery, is strongly protective in preclinical murine models of inflammatory lung injury. The current study was designed to assess the specific contribution of endo...

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Bibliographic Details
Main Authors: Carrie L. Kempf, Saad Sammani, Tadeo Bermudez, Jin H. Song, Vivian Reyes Hernon, Matthew K. Hufford, Jessica Burt, Sara M. Camp, Steven M. Dudek, Joe G. N. Garcia
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Pulmonary Circulation
Subjects:
ARDS
MLCK
Online Access:https://doi.org/10.1002/pul2.12061

Internet

https://doi.org/10.1002/pul2.12061

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