Role of Histone Variant H2A.J in Fine-Tuning Chromatin Organization for the Establishment of Ionizing Radiation-Induced Senescence

Role of Histone Variant H2A.J in Fine-Tuning Chromatin Organization for the Establishment of Ionizing Radiation-Induced Senescence

Purpose: Radiation-induced senescence is characterized by profound changes in chromatin organization with the formation of <i>Senescence-Associated-Heterochromatin-Foci</i> (SAHF) and <i>DNA-Segments-with-Chromatin-Alterations-Reinforcing-Senescence</i> (DNA-SCARS). Important...

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Bibliographic Details
Main Authors: Mutaz A. Abd Al-razaq, Benjamin M. Freyter, Anna Isermann, Gargi Tewary, Adèle Mangelinck, Carl Mann, Claudia E. Rübe
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
histone variant H2A.J
ionizing radiation
radiation-induced senescence
Senescence-Associated Heterochromatin Foci (SAHF)
DNA-Segments with Chromatin Alterations Reinforcing Senescence (DNA-SCARS)
Senescence-Associated Secretory Phenotype (SASP)
Online Access:https://www.mdpi.com/2073-4409/12/6/916

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https://www.mdpi.com/2073-4409/12/6/916

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