Deciphering the Role of Histone Modifications in Uterine Leiomyoma: Acetylation of H3K27 Regulates the Expression of Genes Involved in Proliferation, Cell Signaling, Cell Transport, Angiogenesis and Extracellular Matrix Formation

Deciphering the Role of Histone Modifications in Uterine Leiomyoma: Acetylation of H3K27 Regulates the Expression of Genes Involved in Proliferation, Cell Signaling, Cell Transport, Angiogenesis and Extracellular Matrix Formation

Uterine leiomyoma (UL) is a benign tumor arising from myometrium (MM) with a high prevalence and unclear pathology. Histone modifications are altered in tumors, particularly via histone acetylation which is correlated with gene activation. To identify if the acetylation of H3K27 is involved in UL pa...

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Bibliographic Details
Main Authors: María Cristina Carbajo-García, Lucia de Miguel-Gómez, Elena Juárez-Barber, Alexandra Trelis, Javier Monleón, Antonio Pellicer, James M. Flanagan, Hortensia Ferrero
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomedicines
Subjects:
histone modification
gene expression
angiogenesis
extracellular matrix
uterine leiomyoma
Online Access:https://www.mdpi.com/2227-9059/10/6/1279

Internet

https://www.mdpi.com/2227-9059/10/6/1279

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