Neutrophils Isolated from Septic Patients Exhibit Elevated Uptake of Vitamin C and Normal Intracellular Concentrations despite a Low Vitamin C Milieu

Neutrophils Isolated from Septic Patients Exhibit Elevated Uptake of Vitamin C and Normal Intracellular Concentrations despite a Low Vitamin C Milieu

Vitamin C (ascorbate) plays an important role in neutrophil function and is accumulated by the cells either directly via vitamin C transporters (SVCT) or indirectly following oxidation to dehydroascorbic acid. Septic patients are known to have significantly depleted plasma ascorbate status, but litt...

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Bibliographic Details
Main Authors: Anitra C. Carr, Stephanie Bozonet, Juliet Pullar, Emma Spencer, Patrice Rosengrave, Geoff Shaw
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Antioxidants
Subjects:
ascorbate
vitamin C
dehydroascorbic acid
sepsis
septic shock
neutrophils
Online Access:https://www.mdpi.com/2076-3921/10/10/1607

Internet

https://www.mdpi.com/2076-3921/10/10/1607

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