The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment

The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment

The selective autophagy pathways of xenophagy and mitophagy are initiated when the adaptor NDP52 recruits the ULK1 complex to autophagic cargo. Hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) was used to map the membrane and NDP52 binding sites of the ULK1 complex to unique regions...

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Bibliographic Details
Main Authors: Xiaoshan Shi, Chunmei Chang, Adam L Yokom, Liv E Jensen, James H Hurley
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
autophagy
mitophagy
xenophagy
HDX-MS
coiled-coil
electron microscopy
Online Access:https://elifesciences.org/articles/59099

Internet

https://elifesciences.org/articles/59099

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