In vivo generation of CAR T cells in the presence of human myeloid cells

In vivo generation of CAR T cells in the presence of human myeloid cells

Pre-clinical humanized mouse models are a powerful tool to evaluate immunotherapies. NSG-SGM3 mice reconstituted with human stem cells (huSGM3) develop pronounced human myeloid cells due to transgenic expression of stem cell factor, granulocyte-macrophage colony-stimulating factor, and interleukin-3...

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Bibliographic Details
Main Authors: Naphang Ho, Shiwani Agarwal, Michela Milani, Alessio Cantore, Christian J. Buchholz, Frederic B. Thalheimer
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
macrophage
in vivo gene delivery
shielding
T cell targeted lentiviral vectors
humanized mouse model
innate immune response
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000821

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http://www.sciencedirect.com/science/article/pii/S2329050122000821

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