Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles

Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles

Antiretroviral therapy (ART) for the treatment of HIV-1 requires life-long daily adherence to supress viral replication, and nucleoside reverse transcriptase inhibitors that are commonly used in ART have not been converted into long-acting agents. Here, the authors report two lipophilic tenofovir (T...

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Bibliographic Details
Main Authors: Denise A. Cobb, Nathan Smith, Suyash Deodhar, Aditya N. Bade, Nagsen Gautam, Bhagya Laxmi Dyavar Shetty, JoEllyn McMillan, Yazen Alnouti, Samuel M. Cohen, Howard E. Gendelman, Benson Edagwa
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25690-5

Internet

https://doi.org/10.1038/s41467-021-25690-5

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