Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT1R axis and attenuates cardiac inflammation and apoptosis

Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT1R axis and attenuates cardiac inflammation and apoptosis

Objective: To investigate the cardioprotective effect of beta-glucan against isoproterenol-induced cardiotoxicity in rats, and elucidate the underlying mechanism. Methods: Rats were orally pretreated with beta-glucan (40 mg/kg body weight) for 30 d, and isoproterenol (20 mg/100 g body weight) was ad...

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Bibliographic Details
Main Authors: Anitha Roy, Vasantha Mallenahalli Neelakantappa, Jayashree Ganesan, Balakrishnan Ramajayam Asokan, Srinivasan Kulandaivel, V V Sathibabu Uddandrao, Sengottuvelu Singaravel
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
βeta-glucan; isoproterenol; cardiac inflammation; cardiac apoptosis; cardiovascular diseases; heart failure; myocardial infarction
Online Access:http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=9;spage=384;epage=392;aulast=Roy

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http://www.apjtb.org/article.asp?issn=2221-1691;year=2023;volume=13;issue=9;spage=384;epage=392;aulast=Roy

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