Anabolic effects of IGF-1 signaling on the skeleton

Anabolic effects of IGF-1 signaling on the skeleton

This review focuses on the anabolic effects of IGF-1 signaling on the skeleton, emphasizing the requirement for IGF-1 signaling in normal bone formation and remodeling. We first discuss the genomic context, splicing variants and species conservation of the IGF-1 locus. The modulation of IGF-1 action...

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Bibliographic Details
Main Authors: Candice G. T Tahimic, Yongmei eWang, Daniel D. Bikle
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Endocrinology
Subjects:
Alternative Splicing
Ephrins
Growth Hormone
Integrins
Osteogenesis
Mechanotransduction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00006/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2013.00006/full

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