Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

Abstract Background αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers. Previous studies using human cancer cell lines and human xenograft models have suggested potential tumor promoter (onc...

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Bibliographic Details
Main Authors: Behnam Rashidieh, Amanda Louise Bain, Simon Manuel Tria, Sowmya Sharma, Cameron Allan Stewart, Jacinta Ley Simmons, Pirjo M. Apaja, Pascal H. G. Duijf, John Finnie, Kum Kum Khanna
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Experimental Hematology & Oncology
Subjects:
Cryab mouse model
Tumorigenesis
Metastasis
Angiogenesis
Heat-shock protein
Online Access:https://doi.org/10.1186/s40164-022-00365-z

Internet

https://doi.org/10.1186/s40164-022-00365-z

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