Role of Ubiquitination in PTEN Cellular Homeostasis and Its Implications in GB Drug Resistance

Role of Ubiquitination in PTEN Cellular Homeostasis and Its Implications in GB Drug Resistance

Glioblastoma (GB) is the most common and aggressive brain malignancy, characterized by heterogeneity and drug resistance. PTEN, a crucial tumor suppressor, exhibits phosphatase-dependent (PI3K-AKT-mTOR pathway)/independent (nucleus stability) activities to maintain the homeostatic regulation of nume...

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Bibliographic Details
Main Authors: Qin Xia, Sakhawat Ali, Liqun Liu, Yang Li, Xuefeng Liu, Lingqiang Zhang, Lei Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
glioma
glioblastoma
phosphatase and tensin homolog
ubiquitination
E3 ubiquitin ligases
drug resistance
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01569/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01569/full

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