Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease

Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease

Abstract Background The function of the blood-brain barrier (BBB) is impaired in late-onset Alzheimer disease (LOAD), but the associated molecular mechanisms, particularly with respect to the high-risk APOE4/4 genotype, are not well understood. For this purpose, we developed a multicellular isogenic...

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Bibliographic Details
Main Authors: Undine Haferkamp, Carla Hartmann, Chaudhry Luqman Abid, Andreas Brachner, Alevtina Höchner, Anna Gerhartl, Bernadette Harwardt, Selin Leckzik, Jennifer Leu, Marco Metzger, Marina Nastainczyk-Wulf, Winfried Neuhaus, Sabrina Oerter, Ole Pless, Dan Rujescu, Matthias Jung, Antje Appelt-Menzel
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Fluids and Barriers of the CNS
Subjects:
Apolipoprotein E
Human induced pluripotent cells
Blood-brain barrier
Neurovascular unit
Alzheimer disease
Late-onset Alzheimer disease
Online Access:https://doi.org/10.1186/s12987-023-00471-y

Internet

https://doi.org/10.1186/s12987-023-00471-y

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