Characterisation of the Molecular Mechanism of Permeation of the Prodrug Me-5ALA across the Human <i>Stratum Corneum</i> Using Molecular Dynamics Simulations

Characterisation of the Molecular Mechanism of Permeation of the Prodrug Me-5ALA across the Human <i>Stratum Corneum</i> Using Molecular Dynamics Simulations

The barrier imposed by the outer layer of the skin, the <i>stratum corneum</i>, creates an almost impermeable environment for exogenous substances. Few lipophilic drugs with low molecular mass can passively diffuse through this layer, highlighting the need to develop methods to enable th...

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Bibliographic Details
Main Authors: Janonna Kadyrov, Lanie Ruiz-Perez, Heather A. E. Benson, Ricardo L. Mancera
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
transdermal drug delivery
drug lipidation
prodrug
drug permeation
lipid bilayer
Online Access:https://www.mdpi.com/1422-0067/23/24/16001

Internet

https://www.mdpi.com/1422-0067/23/24/16001

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