Stereoselective alkoxycarbonylation of unactivated C(sp3)–H bonds with alkyl chloroformates via Pd(II)/Pd(IV) catalysis
Carbonylation of unactivated C-H bonds is typically carried out on primary C-H sites using gaseous carbon monoxide. Here the authors report a palladium cataylsed alkoxycarbonylation process using alkyl chloroformates that functionalises more challenging unactivated secondary C-H sites.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12901 |